JBScreen JCSG++ is a sparse matrix screen optimized for initial screening of crystallization conditions of biological macromolecules. The screen has been formulated by researchers from the Joint Center for Structural Genomics (JCSG)[1] and from the European Genomics Consortium[2].
A core set of 66 conditions used by the JCSG for high-throughput structure determination was expanded to 96 screening conditions to round out the pH profile and include various precipitants such as succinate, malonate and formate.
When JBScreen JCSG++ is used along with JBScreen PACT++, the benefits of a sparse matrix screen can be combined with the systematic investigation of the precipitation behaviour of the protein.
| Item | Cat. No. | Amount | Price |
|---|---|---|---|
| JBScreen JCSG++ 1 | CS-151 | 24 solutions (10 ml each) | 352,00 € |
| JBScreen JCSG++ 2 | CS-152 | 24 solutions (10 ml each) | 352,00 € |
| JBScreen JCSG++ 3 | CS-153 | 24 solutions (10 ml each) | 352,00 € |
| JBScreen JCSG++ 4 | CS-154 | 24 solutions (10 ml each) | 352,00 € |
| JBScreen JCSG++ Set 1 - 4 | CS-155 | 4 Kits | 1.126,40 € |
| JBScreen JCSG++ HTS | CS-206L | 96 solutions (1,7 ml each) | 563,20 € |
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[1] Page et al. (2004) Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome. Acta Cryst. D 59:1028.
[2] Newman et al. (2005) Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy. Acta Cryst. D 61:1426.
