In a recent Cell paper[1], Glaser, Uhlmann and colleagues show that the replication machinery (replisome) can physically pass through the ring-shaped cohesin complex during DNA replication. We are honored that various nucleotide reagents from Jena Bioscience contributed to the success of this ambitious group of scientists, helping them to truly advance in the field of replication & chromatin research.
Using reconstituted biochemical systems and single-molecule fluorescence microscopy, they show that the replisome, aided by DNA polymerases α and ε, can move through cohesin without disassembling it. This ensures that both sister chromatids remain enclosed within the same ring for faithful chromosome segregation.
Read more: access the full article here!
| Product | Cat. No. | Amount / Reactions | Price |
|---|---|---|---|
| ATPγS | NU-406-5 | 5 mg | 100,30 € |
| NU-406-25 | 25 mg | 274,60 € | |
| NU-406-50 | 50 mg | 497,00 € | |
| AppNHp (AMPPNP) |
NU-407-10 | 10 mg | 108,10 € |
| NU-407-50 | 50 mg | 362,80 € | |
| dNTP Bundle | NU-1005S | 4 x 200 µl (4 x 20 µmol) | 81,10 € |
| NU-1005L | 4 x 1 ml (4 x 100 µmol) | 323,90 € | |
| ATP - Solution | NU-1010 | 1 ml (100 mM) | 51,60 € |
| NTP Bundle | NU-1014S | 4 x 200 µl (4 x 20 µmol) | 44,20 € |
| NU-1014L | 4 x 1 ml (4 x 100 µmol) | 176,10 € |
[1] Glaser et al (2025) Replisome passage through the cohesin ring. Cell 188:1; https://doi.org/10.1016/j.cell.2025.08.028
