Breaking new grounds in biosensing & imaging

Here we introduce a highly versatile tool for bioconjugation, -sensing and -imaging.
Check out more below!

Functionalized nanoparticles are a growing field of research due to their ability to bind a wide range of biomolecules (e.g. peptides, antibodies or DNA) covalently.

Especially gold nanorods (Au NRs) with their anisotropic, rod-like morphology (Fig. 1), optical properties & variable shapes (4 x 60 nm, 8 x 80 nm) are suitable for multifunctional biological and medical applications that go far beyond bioconjugation, including:

• Biosensing: surface and dielectric properties enable highly specific & selective biosensing^[1]
• Bioimaging: gold as an inert & biocompatible material with high electron density is ideally suitable as bioimaging agent^[2]
• Targeted drug delivery: due to a large surface area and bioconjugation ability Au NRs serve as suitable vehicles for targeted drug/gene delivery^[3]
• Photothermal therapeutic treatment: Au NRs convert light energy (NIR) into heat thus enabling destruction of pathological (e.g. cancerous) tissue & cells^[3]

E-Mail me for technical inquiries or further information: pcr@jenabioscience.com

References:

[1] Stone et al. (2011) Biological applications of gold nanorods. John Wiley & Sons, Inc. 3:100.
[2] Baumann et al. (2016) Highly stable and biocompatible gold nanorod-DNA conjugates as NIR probes for ultrafast sequence-selective DNA melting. RSC Adv. 6:103724.
[3] Elahi et al. (2018) Recent biomedical applications of gold nanoparticles: A review. Talanta 184:537.