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evoglow^® – Anaerobic Fluorescent Proteins

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FORGET ABOUT OXYGEN –
USE EVOGLOW^® PROTEINS!

evoglow^® proteins are a major breakthrough especially in the field of hypoxia research. This patented technology provides new fluorescent proteins that fluoresce under aerobic and anaerobic conditions.

evoglow^® proteins are fluorescent reporters derived from YtvA – a blue-light-receptor-protein from Bacillus subtilis.

This receptor naturally acts as sensory protein with regulatory functions. Directed mutagenesis of the active site led to fluorescent mutants that can be used in both aerobic and anaerobic biological systems [1] and can be expressed in various hosts ranging from gram-positive and gram-negative bacteria to yeast [2].

These new fluorescent proteins provide crucial research tools for physiological in situ studies of pathogenic fungi like C. albicans under conditions of hypoxia [3]. Furthermore, evoglow^® proteins have been successfully applied as model proteins in automated high-throughput fermentation [4].

Structure of an evoglow protein with a bound chromophore

Please check our website for detailed information on evoglow^® proteins:

www.jenabioscience.com/cms/en/1/browse/1362/

References:
[1] Drepper et al. (2007) Reporter proteins for in vivo fluorescence without oxygen. Nature Biotech. 25 (4):443.
[2] Tielker et al. (2009) Flavin Mononucleotide-Based Fluorescent Protein as an Oxygen-Independent Reporter in Candida albicans and Saccharomyces cerevisiae. Eukaryotic Cell 8 (6):913.
[3] Ernst et al. (2009) Responses to hypoxia in fungal pathogens. Cellular Microbiology 11 (2):183.
[4] Huber et al. (2009) Robo-Lector – a novel platform for automated high-throughput cultivations in microtiter plates with high information content. Microbial Cell Factories 8:42.

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