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   Crystallization News, Issue May 2011
   
   


* In this issue:

(1) Pi-minimal Screen & Pi-PEG Screen – Incomplete factorial design for diversity of crystallization conditions!
(2) Dual-Thickness MicroMounts – Superior features unlike any other mount!
(3) High-throughput Crystal Former – Harness the power of diffusive mixing!

   
       
  
   
   

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    (1) Pi-minimal Screen & Pi-PEG Screen – Incomplete factorial design for diversity of crystallization conditions!
   

The Pi-minimal Screen and the Pi-PEG Screen were developed at the MRC Laboratory of Molecular Biology (Cambridge, UK) for efficient crystallization screening of soluble proteins and integral membrane proteins, respectively [1]. Both screens are based on incomplete factorial design.

The unique formulation of both screens was generated following a strategy named Pi sampling[1] in order to create novel combinations of precipitants, buffers and additives across a standard 96-condition plate layout. Thus, the diversity amongst the crystallization conditions is ideal for initial screening.

Find more about the formulation, e.g. the employed buffer systems, of the Pi-minimal Screen at: www.jenabioscience.com/cms/en/1/catalog/1620/

Benefit from the experience of membrane protein crystallization at the MRC and read more about the Pi-PEG Screen under: www.jenabioscience.com/cms/en/1/catalog/1621/


Reference:
[1] Gorrec et al. (2011) Pi sampling: a methodical and flexible approach to initial macromolecular crystallization screening. Acta Cryst. D67:463.


   
    (2) Dual-Thickness MicroMounts – Superior features unlike any other mount!
   

Utilizing advanced proprietary micro-fabrication processes, the Dual-Thickness MicroMounts have a thick, semi-rigid body and a thin, highly X-ray transparent crystal-receiving aperture. This dual thickness maximizes durability and rigidity, while maintaining the ultra-low X-ray background scatter that original MicroMounts™ are known for.

Benefits:
  • Lowest X-ray Background
  • Greater Rigidity
  • Easier Harvesting
  • Lower Vibration
  • Easier Auto-Centering
  • Maximum Durability
  • You find more information under: www.jenabioscience.com/cms/en/1/catalog/1643/


       
        (3) High-throughput Crystal Former – Harness the power of diffusive mixing!
       


    The new High-throughput Crystal Former is now available with 96-microchannels arranged on a SBS-footprint plate.

    Like the original Crystal former, the microfluidic device exploits favorable physical conditions for straightforward crystal growth occurring at the microscale.

    Read more about the High-throughput Crystal Former and other available Crystal Former formats under:

    www.jenabioscience.com/cms/en/1/catalog/1307/


       
       

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