New in stock: Modified and Unmodified Nucleosides

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We are happy to announce that our portfolio of unmodified and modified nucleosides has been greatly extended.

Nucleoside analogs play an increasingly important role in research, diagnosis, and therapy of diseases such as cancer and viral infections including AIDS, herpes, and hepatitis[1],[2],[3],[4],[5]. Furthermore, fluorescent nucleosides have become valuable probes for detection of hybridisational and conformational changes in DNA microenvironment[6],[7].
Finally, modified nucleosides serve as building blocks for phosphoramidite and pharmaceutical oligonucleotide synthesis and are used as starting material for preparation of their corresponding nucleoside 5'-mono-, di- and triphosphates.

Search through our nucleoside product range either by chemical structure or by application:

Nucleosides sorted by chemical structure

  • Unprotected Nucleosides

  • N-protected Nucleosides

  • 5'-DMT-protected Nucleosides

Nucleosides sorted by special applications

Nucleoside and nucleotide analogs not on stock may be available as custom synthesis, just send us an e-mail at nucleotides@jenabioscience.com with any questions you may have!

Selected references:
[1] Gosselin et al. (1991) Nucleoside analogs as chemotherapeutic agents: a review. Nucleosides and Nucleotides 11(2-4):903.
[2] Eric de Clercq (2005) Antiviral drug discovery and development: where chemistry meets with biomedicine. Antiviral Research 67:56.
[3] Mathé et al. (2006) L-Nucleoside enantiomers as antiviral drugs: a mini-review. Antiviral Research 71:276.
[4] Seidel et al. (2006) Modified nucleosides: an accurate tumor marker for clinical diagnosis of cancer, early detection and therapy control. Br. J. Cancer 94:1726.
[5] Bullinger et al. (2007) Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. BMC Biochem. 29:25.
[6] Dodd and Hudson (2009) Intrinsically fluorescent base-discriminating nucleoside analogs. Mini-Reviews in Organic Chemistry 6(4):378.
[7] Mary E. Hawkins (2003) Pharmacological and Experimental Therapeutic Section in Topics in Fluorescence Spectroscopy, Volume 7: DNA Technology, Kluwer Academic/Plenum Publishers, New York

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