Jena Bioscience - Newsletter

Nucleoside analogs play an increasingly important role in research, diagnosis, and therapy of diseases such as cancer and viral infections including AIDS, herpes, and hepatitis^{[1],[2],[3],[4],[5]}. Furthermore, fluorescent nucleosides have become valuable probes for detection of hybridisational and conformational changes in DNA microenvironment^[6],[7].
Finally, modified nucleosides serve as building blocks for phosphoramidite and pharmaceutical oligonucleotide synthesis and are used as starting material for preparation of their corresponding nucleoside 5'-mono-, di- and triphosphates.

Search through our nucleoside product range either by chemical structure or by application:

Nucleoside and nucleotide analogs not on stock may be available as custom synthesis, just send us an e-mail at nucleotides@jenabioscience.com with any questions you may have!

Selected references:
[1] Gosselin et al. (1991) Nucleoside analogs as chemotherapeutic agents: a review. Nucleosides and Nucleotides 11(2-4):903.
[2] Eric de Clercq (2005) Antiviral drug discovery and development: where chemistry meets with biomedicine. Antiviral Research 67:56.
[3] Mathé et al. (2006) L-Nucleoside enantiomers as antiviral drugs: a mini-review. Antiviral Research 71:276.
[4] Seidel et al. (2006) Modified nucleosides: an accurate tumor marker for clinical diagnosis of cancer, early detection and therapy control. Br. J. Cancer 94:1726.
[5] Bullinger et al. (2007) Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. BMC Biochem. 29:25.
[6] Dodd and Hudson (2009) Intrinsically fluorescent base-discriminating nucleoside analogs. Mini-Reviews in Organic Chemistry 6(4):378.
[7] Mary E. Hawkins (2003) Pharmacological and Experimental Therapeutic Section in Topics in Fluorescence Spectroscopy, Volume 7: DNA Technology, Kluwer Academic/Plenum Publishers, New York