| |
|
|
| |
 |
Non-hydrolyzable Nucleotides from Jena Bioscience |
|
|
|
| |
|
|
 |
| |
|
|
| |
Please click here if this newsletter is not displayed properly!
|
|
| |
|
|
| |
Nucleotide analogs that are resistant to hydrolysis are suitable tools for the trapping of kinases, G-proteins, motor proteins, chaperones, or any other NTP-binding enzymes in their triphosphate-bound state. They are also useful as inhibitors for co-crystallization, kinetic assays, or as biochemical probes.
The following is a selection of Jena Bioscience analogs that have recently been reported in the literature:
|
|
|
ATPγS (JBS Cat.No. NU-406) more...
|
| |
|
Authors:
|
Tania Matamoros, Jérôme Deval, Catherine Guerreiro, Laurence Mulard, Bruno Canard and Luis Menéndez-Arias
|
|
Journal:
|
J. Mol. Biol. (2005), 349 (3):451-463.
|
|
Title:
|
Supression of Multidrug-resistant HIV-1 Reverse Transscriptase Primer Unblocking Activity by a-Phosphate-modified Thymidine Analogues
|
|
Application:
|
Studies on the ATP-dependent phosphorolytic activity of multidrug-resistant HIV-1 Reverse Transcriptase
|
|
|
|
GTPγS (JBS Cat.No. NU-412) more...
|
| |
|
Authors:
|
Fu-Jung Chang, Scott Lemme, Qian Sun, Roger K. Sunahara, and Annie Beuve
|
|
Journal:
|
J. Biol.Chem. (2005), 280 (12):11513-11519.
|
|
Title:
|
Nitric Oxide-dependent allosteric Inhibitory Role of a Second Nucleotide Binding Site in Soluble Guanylyl Cyclase
|
|
Application:
|
Measuring effects of various nucleotide analogs on the activity of soluble guanylyl cyclases (sGC) in the presence of NO
|
|
|
|
GpCpp (JBS Cat.No. NU-405) more...
|
| |
|
Authors:
|
Andrew D. Franck, Andrew F. Powers, Daniel R. Gestaut, Tamir Gonen, Trisha N. Davis, Charles L. Asbury
|
|
Journal:
|
Nature Cell Biology (2007), 9 (7):832-837.
|
|
Title:
|
Tension applied through the Dam1 complex promotes microtubule elongation providing a direct mechanism for length control in mitosis
|
|
Application:
|
Study on the mechanism of microtubule-length control in mitosis
|
|
|
|
mant-GTPγS (JBS Cat.No. NU-209) more...
|
| |
|
Authors:
|
Daniel Monléon, Marta Martínez-Vicente, Vicent Esteve, Lucia Yim, Silvia Prado, Maria-Eugenia Armengod, Bernardo Celda
|
|
Journal:
|
PROTEINS: Structure, Function, and Bioinformatics (2007), 66:726-739.
|
|
Title:
|
Structural Insights Into the GTPase Domain of Escherichia coli MnmE Protein
|
|
Application:
|
Fluorescent probe for guanine nucleotide binding of E. coli MnmE protein and its G-domain (GTPase)
|
|
|
|
mant-GppNHp (JBS Cat.No. NU-207) more...
|
| |
|
Authors:
|
Yevgeny Berdichevsky, Ariel Mizrahi, Yelena Ugolev, Shahar Molshanski-Mor, Edgar Pick
|
|
Journal:
|
J. Biol. Chem. (2007), 282 (30):22122-22139.
|
|
Title:
|
Tripartite Chimeras Comprising Functional Domains Derived from the Cytosolic NADPH Oxidase Components p47phox, p67phox, and Rac1 Elicit Activator-independent Superoxide Production by Phagocyte Membranes
|
|
Application:
|
Fluorescent probe for GTP-binding of Rac1 and its ligands
|
|
|
|
dUpNHpp (JBS Cat.No. NU-903) more...
|
| |
|
Authors:
|
Veronika Németh-Pongrácz, Orsolya Barabás, Mónika Fuxreiter, István Simon, Iva Pichová, Michalea Rumlová, Helena Zábranská, Dmitri Svergun, Maxim Petoukhov, Veronika Harmat, Éva Klement, Éva Hunyadi-Gulyás, Katalin F. Medzihradszky, Emese Kónya and Beáta G. Vértessy
|
|
Journal:
|
Nucleic Acids Research (2007), 35 (2):495-505.
|
|
Title:
|
Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins
|
|
Application:
|
Crystallization of the Mason-Pfizer monkey virus dUTPase in complex with dUpNHpp and determination of its X-ray structure
|
To browse our whole portfolio of non-hydrolyzable nucleotides please visit:
http://www.jenabioscience.com/cms/en/1/browse/227/
If you require nucleotide analogs that are not on stock please send us an e-mail at nucleotides@jenabioscience.com to receive a quote for a custom synthesis.
|
|
|
| |
If you wish not to receive further email newsletters from us, please reply to this E-mail with the subject "UNSUBSCRIBE" or unsubscribe via the form at our website at www.jenabioscience.com.
|
|
|
| |
|
|
|
Responsible for content / Imprint
|
| |
Jena Bioscience GmbH
Loebstedter Str. 80
07749 Jena
Germany
Phone:+49 – 3641 – 6285 000
Fax: +49 – 3641 – 6285 100
E-Mail: info@jenabioscience.com
Register Court: Amtsgericht Jena, HRB 207171
VAT No.: DE 195825742
Managing Directors:
Thomas Billert
Dr. Mathias Grün
|
|
| |
|
|
|
www.jenabioscience.com
|
| |
|
|
