The enzymes involved in hydrolysis of nucleoside triphosphates are a major focus of biochemical research, targeting the understanding and treatment of cellular processes involved in diseases such as cancer, viral infections, cardiovascular and motional disorders. To elucidate the mechanisms of action of these enzymes, it is often desirable to trap the enzymes in their triphosphate-bound state.

Natural nucleotides are hydrolyzed at rates usually preventing such studies therefore, nucleotide analogs with modified phosphate moieties are used which are hydrolyzed at much smaller rates or that are even completely resistant to hydrolysis.

The position of the modification within the triphosphate has a strong influence on its binding affinity to a particular enzyme and its hydrolysis rate.

With the new Non-hydrolyzable Nucleotide Test Kits, there is now a convenient tool to rapidly identify the most suitable non-hydrolyzable ATP or GTP derivative for your application.

Each Non-hydrolyzable Nucleotide Test Kit contains a set of 5 typical non-hydrolyzable nucleotides, ATP or GTP analogs, respectively.

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