home
           
   
     Nourseothricin – Superior Selection Antibiotic in Molecular Genetics
   
   
   
       
  		    
    Please click here if this newsletter is not displayed properly!    
   

What is Nourseothricin?
  • Streptothricin antibiotic for a broad spectrum of viruses, bacteria and other unicellular or complex organisms

  • Preferred selection antibiotic for genetically modified
    • Gram-positive and Gram-negative bacteria
    • yeast and filamentous fungi
    • protozoa, plants... and many more

Advantages:
  • Very broad spectrum of activity; for a list of sensitive hosts, please refer the table below or to the Nourseothricin data sheet
  • Low or no background: Resistance protein is localized intracellularly and cannot be degraded in the cell culture medium
  • Not used in human or veterinary medicine; therefore, no conflict with regulatory requirements
  • No cross-reactivity with other aminoglycosid antibiotics such as Hygromycin or Geneticin
  • No cross-resistance with therapeutic antibiotics
  • Long-term stable as powder or solution
  • Highly soluble in water (1 g/L)

Nourseothricin is marketed by Jena Bioscience as "LEXSY NTC"
(it is also known as NTC or clonNAT)

Please see the NTC section of our website for details!


For structure formula, mechanism of action, list of sensitive organisms and literature please see our Nourseothricin overview.

List of Nourseothricin sensitive organisms

Group Species MIC*
µg/ml		 Selection conc.
µg/ml
Gram-negative bacteria Escherichia coli 2-12 50
Francisella tularensis
5
Pseudomonas aeruginosa 50 100
Gram-positive bacteria Bacillus subtilis 5 50
Enterococcus faecium 8-256 500
Staphylococcus aureus 2-12 50
Streptomycetes Streptomyces lividans 6 100
Yeast Candida albicans 200 250-450
Cryptococcus neoformans
100
Hansenula polymorpha
100
Pichia pastoris
100
Saccharomyces cerevisiae 25 100
Filamentous fungi Acremonium chrysogenum
25
Sordaria macrospora
50
Ustilago maydis
75
Protozoa Leishmania tarentolae
100
Phytomonas serpens
100
Plasmodium falciparum 75**
Toxoplasma gondii
500
Plants Arabidopsis thaliana 20 200
Oryza sativa 20 200

* MIC: Minimal inhibitory concentration
** IC50: Concentration inhibiting growth by 50%


Please contact us at info@jenabioscience.com with questions or inquiries.


   
   

If you wish not to receive further email newsletters from us, please reply to this E-mail with the subject "UNSUBSCRIBE" or unsubscribe via the form at our website at www.jenabioscience.com.
 

    
   
   
    Responsible for content / Imprint   
   
Jena Bioscience GmbH
Loebstedter Str. 80
07749 Jena
Germany

Phone:+49 – 3641 – 6285 000
Fax: +49 – 3641 – 6285 100
E-Mail: info@jenabioscience.com

Register Court: Amtsgericht Jena, HRB 207171
VAT No.: DE 195825742

Managing Directors:
Thomas Billert
Dr. Mathias Grün 		   
           
    www.jenabioscience.com   
           
      © 2009 Jena Bioscience GmbH - Imprint