Extended range of Click Chemistry Reagents from Jena Bioscience

(1) Alkyne-containing phosphoramidites
(2) Propargyl-CPGs
(3) Alkyne-, DBCO-, and Azide-reagents

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Click Chemistry has become an efficient and widely used labeling technique. We are happy to announce that our portfolio of Click Chemistry reagents has been extended by numerous Alkyne-containing Phosphoramidites and 2'-O- and 3'-O-Propargyl-CPGs (Controlled Pore Glasses) for synthesis of oligonucleotides by automated standard protocols.

The resulting oligos contain reactive groups (triple bonds) for subsequent CLICK-attachment of reporter groups such as biotin or fluorescent dyes, allowing synthesis of highly modified DNA strands carrying multiple labels in a density unmatched by classic labeling techniques[1]. The labeled oligos may serve as PCR primers[2], antisense agents for therapeutic applications[3],[4], molecular beacons for detecting genetic mutations, and as probes for measuring gene expression in DNA microarrays[5] and gene chips.

   Alkyne-containing Phosphoramidites
Figure 1: Molecular structure of 2'-O-Propargyl-3'-CEP Adenosine (Bz) [Cat.No.: CLK-ANP-7751]

We offer a large selection of phosphoramidites [e.g. 2'-O-Propargyl-3'-CEP Adenosine (Bz), Fig. 1] for synthesis of oligonucleotides by automated standard protocols, including:

  • 2'-O-Propargyl / 3'-O-Propargyl-CEPs of A, C, G, U, I
  • 5-Alkynylated-CEPs of dU / dC

For more detailed information please click here:


    2'-O- and 3'-O-Propargyl-CPGs

In addition, we offer a large variety of CPGs (Controlled Pore Glasses) as supports for the synthesis of oligonucleotides by automated standard protocols, including:

  • 2'-O-Propargyl / 3'-O-Propargyl-CPGs of A, C, G, U, I - available with 500 Å or 1000 Å pore sizes either as bulk material or in pre-filled columns

For more detailed information please click here:


    Jena Bioscience's product line of Click Chemistry Reagents also contains:

Click Chemistry Kits
Other Alkyne-containing CPGs
Alkyne-containing Nucleosides
Alkyne-containing Spacers
Alkyne-containing Nucleotides
Alkyne-containing Fluorescent Dyes
Alkyne-containing Phosphoramidites
Auxiliary Reagents
2'-O- and 3'-O-Propargyl CPGs


DBCO-containing Chemical Modification Reagents
DBCO-containing Spacers
DBCO-containing Biotinylation Reagents
DBCO-containing Fluorescent Dyes

Non-Fluorescent Azides
Azides of Fluorescent Dyes
Biotin Azides
Azides of Quencher Dyes
PEG and Spacer Azides
Nucleotide Azides
Azides of Amino Acids


Selected References:
[1] Kiviniemi et al. (2010) Solid-supported synthesis and click conjugation of 4'-C-alkyne functionalized oligodeoxyribonucleotides. Bioconjugate Chem. 21:1890.
[2] Ju et al. (2003) Click chemistry to construct fluorescent oligonucleotides for DNA sequencing. J. Org. Chem. 68:609.
[3] Ma et al. (2000) Oligonucleotides as therapeutics: the coming of age. Biotechnol. Annu. Rev. 5:155.
[4] Herdewijn (2005) Methods in Molecular Biology, Ed. Oligonucleotide Synthesis: Methods and Applications; Human Press Inc: Totowa 288.
[5] Collman et al. (2005) Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers. J. Am. Chem Soc. 127:8600.


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Dr. Mathias Grün
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