(1) Alkyne-containing phosphoramidites
(2) Propargyl-CPGs
(3) Alkyne-, DBCO-, and Azide-reagents

Click Chemistry has become an efficient and widely used labeling technique. We are happy to announce that our portfolio of Click Chemistry reagents has been extended by numerous Alkyne-containing Phosphoramidites and 2'-O- and 3'-O-Propargyl-CPGs (Controlled Pore Glasses) for synthesis of oligonucleotides by automated standard protocols.

The resulting oligos contain reactive groups (triple bonds) for subsequent CLICK-attachment of reporter groups such as biotin or fluorescent dyes, allowing synthesis of highly modified DNA strands carrying multiple labels in a density unmatched by classic labeling techniques^[1]. The labeled oligos may serve as PCR primers^[2], antisense agents for therapeutic applications^[3],[4], molecular beacons for detecting genetic mutations, and as probes for measuring gene expression in DNA microarrays^[5] and gene chips.

Figure 1: Molecular structure of 2'-O-Propargyl-3'-CEP Adenosine (Bz) [Cat.No.: CLK-ANP-7751]

We offer a large selection of phosphoramidites [e.g. 2'-O-Propargyl-3'-CEP Adenosine (Bz), Fig. 1] for synthesis of oligonucleotides by automated standard protocols, including:

• 2'-O-Propargyl / 3'-O-Propargyl-CEPs of A, C, G, U, I
• 5-Alkynylated-CEPs of dU / dC

For more detailed information please click here:

www.jenabioscience.com/cms/en/1/catalog/1380

In addition, we offer a large variety of CPGs (Controlled Pore Glasses) as supports for the synthesis of oligonucleotides by automated standard protocols, including:

• 2'-O-Propargyl / 3'-O-Propargyl-CPGs of A, C, G, U, I - available with 500 Å or 1000 Å pore sizes either as bulk material or in pre-filled columns
  

For more detailed information please click here:

www.jenabioscience.com/cms/en/1/catalog/1612

If you wish not to receive further email newsletters from us, please reply to this E-mail with the subject "UNSUBSCRIBE" or unsubscribe via the form at our website at www.jenabioscience.com.