* In this issue:

(1) Metal Affinity Chromatography Media & Kits
(2) Protein A Affinity Media

Immobilized metal affinity chromatography is a widely used protein purification technique. It is based on the interaction between certain exposed protein residues (histidines, cysteines, tryptophanes) with transition metal cations.

Jena Bioscience has extended its Affinity Chromatography section by a large selection GRAVITY FLOW CHELATING AGAROSE BEADS for the purification of His-tagged proteins!

Our product range covers four different types of metals: Nickel Cobalt Zinc Copper and two different densities of groups on the beads: high density (High binding capacity) low density (High selectivity)

Although Nickel and Cobalt are the most widely used, sometimes Zinc and Copper are more appropriate for particular purifications. These products allow purifications where Nickel or Cobalt may cause inhibition, or irreversible adsorption of the target-protein.

• Metal free media – allow addition of the corresponding metal ions by the user prior to use of the material for protein purification.

For more detailed product information please refer to:

www.jenabioscience.com/cms/feature/1/catalog/1314/

The easiest way to determine the most suitable chelating agarose material for your particular purification task is the usage of one of our Chelate Kits.

Check out our Test kit section at:

www.jenabioscience.com/cms/feature/1/catalog/1315/

Protein A is a cell wall component of Staphylococcus aureus. It consists of a single polypeptide chain shaped as a cylinder, which contains five antibody binding domains. These high affinity regions are specifically bound to the Fc region of immunoglobulins (IgGs).

Protein A is temperature stable and it retains its native conformation even in the presence of denaturing agents. Protein A resins have been widely used to purify a broad range of immunoglobulins from different mammalian species.

Jena Bioscience has launched a new product section of Protein A containing affinity material! Please browse this section at:

www.jenabioscience.com/cms/feature/1/catalog/1313/

We offer Protein A products with competitive advantages compared to market standards:

• high IgG-binding capacity resin (around 25 mg human IgG/ml)
• milder elution condition than Protein G resin
• high stability binding of Protein A: resin is reusable with no significant loss of binding capacity

• bulk resins
• pre-packed columns

Make sure you check out our entire product line of Affinity Chromatography products at:

www.jenabioscience.com/cms/feature/1/browse/802/

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