Catalog DBCO Reagents - Biotinylation ReagentsDBCO Reagents - Biotinylation Reagents
 
 
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Fluorescent Dyes   |   Biotinylation Reagents   |   FLAG Reagents   |   Bifunctional Reagents   |   PEGylation Reagents   |   Nucleotides   |   DBCO Agarose   |   DBCO Magnetic Beads
 
Labeling of a molecule (e.g. a protein or nucleic acid) with biotin is routinely performed for its subsequent affinity purification via streptavidin agarose or detection with fluorescent or HRP-labeled streptavidin. Due to the extremely high affinity of biotin towards streptavidin (KD = 10-15 M), the biotinylated molecule/streptavidin-interaction is essentially irreversible under physiological conditions.

Dibenzocyclooctyne (DBCO)*-containing biotinylation reagents can be used for the labeling of Azide-tagged biomolecules via Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC).

A number of biotinylation reagents with

  • different solubility characteristics (PEG- and Sulfo-linker for increased molecule solubility)
  • optimized streptavidin binding characteristics (different PEG-linker length)
  • different cleavability characteristics (Diazo- and Sulfhydryl-linker for removal of the biotin moiety upon purification)
are available to fit specific application & molecule requirements.

*DBCO is also known as ADIBO (= Azadibenzocyclooctyne) or DIBAC (= Dibenzoazacyclooctyne)

Click Chemistry background information
 

DBCO-PEG4-Biotin Conjugate
Dibenzylcyclooctyne-PEG4-Biotin Conjugate
   
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-A105P4-10 10 mg 148,50    Add this product to your notepad  
100 mg pack CLK-A105P4-100 100 mg 895,00    Add this product to your notepad

 
DBCO-PEG12-Biotin Conjugate
Dibenzylcyclooctyne-PEG12-Biotin Conjugate
   
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-A105P12-10 10 mg 234,96    Add this product to your notepad  
25 mg pack CLK-A105P12-25 25 mg 518,80    Add this product to your notepad

 
Sulfo-DBCO-Biotin Conjugate
Sulfo-Dibenzylcyclooctyne-Biotin Conjugate
   
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-A116-10 10 mg 148,50    Add this product to your notepad  
100 mg pack CLK-A116-100 100 mg 1.228,42    Add this product to your notepad

 
DBCO-S-S-PEG3-Biotin
Dibenzylcyclooctyne-S-S-PEG3-Biotin Conjugate
   
Product Cat. No. Amount Price (EUR) Buy / Note  
25 mg pack CLK-A112-25 25 mg 337,23    Add this product to your notepad  

 
Diazo Biotin-DBCO    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-1043-10 10 mg 183,48    Add this product to your notepad  
100 mg pack CLK-1043-100 100 mg 1.122,38    Add this product to your notepad

 
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