GTPases of the Ras superfamily represent a group of more than fifty proteins that function as molecular switches controlling a variety of signaling and transport pathways essential for numerous cellular functions. They were grouped, according to sequence homologies, into five principal branches: Ras family, Rab family, Ran family, Rho/Rac/Cdc42 family and Sar1/Arf family.

Ran (Ras-related nuclear protein) is involved in diverse cellular processes like nucleo-cytosplasmic transport of proteins into the nucleus and RNA into the cytoplasm, mitotic spindle assembly, and post-mitotic nuclear assembly. The Ran-regulated nucleo-cytoplasmic transport through the nuclear core complex occurs in conjunction with importins and exportins.

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