Catalog PI 3-Kinase Family - Adaptor ProteinsPI 3-Kinase Family - Adaptor Proteins
 
 
PI3Kα   |   PI3Kβ   |   PI3Kγ   |   PI3Kδ   |   Adaptor Proteins   |   Substrates   |   Inhibitors   |   PI3K Assay
 
Activated PI 3-kinases are composed of a catalytic subunit (p110alpha, p110beta or p110delta) associated with one of a large family of regulatory subunits (p85alpha, p85beta, p55gamma, p55alpha, and p50alpha).
The p85 subunit exists in two isoforms p85alpha and p85beta. It contains two SH2 domains that bind to tyrosine-phosphorylated growth factor receptors or substrate adaptor proteins. It also contains a BH (breakpoint cluster region homology) domain that shows GAP activity towards the small GTPases Rab4, Rab5, Cdc42, Rac1 and to a lesser extend towards Rab6 and Rab11.
It was shown that p110alpha catalytic subunit mediated phosphorylation of the p85alpha adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3-phosphorylated phosphoinositides.
p110alpha protein kinase activity has been implicated in IRS 1 serine phosphorylation in insulin-treated adipocytes and in STAT3 and IRS 1 phosphorylation upon activation of the type 1 IFN receptor by IFN α.
 

Product Accession No. Cat. No. Amount Price (EUR) Buy / Note Downloads
p85 α
Phosphoinositide 3-Kinase regulatory subunit
bovine, recombinant, Leishmania tarentolae
NM_174575 PR-342 20 g 190,00    Add this product to your notepad  
p85 β
Phosphoinositide 3-Kinase regulatory subunit
bovine, recombinant, Sf9 cells
NP_777001.1 PR-942 10 g 190,00    Add this product to your notepad  

For inquiries or further information, please contact us at proteins@jenabioscience.com