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Alkyne-containing Reagents for Cu(I)-catalyzed Click Reactions
One of the most popular reactions within the click chemistry paradigm is the Cu(I)-catalyzed 1,3-dipolar Huisgen cycloaddition of alkynes and azides, using a Copper (Cu) catalyst at room temperature. This reaction proceeds with great efficiency and selectivity in aqueous media and yields a triazole moiety. |
Assay Kits
Easy to use kits containing all reagents required for the detection of cell proliferation via labeling of incorporated EdU by Cu-catalyzed azide-alkyne cycloaddition reactionClick Chemistry Kits
Easy to use kits containing all reagents required for labeling of alkyne-modified oligonucleotides or alkyne-modified PCR products with marker azides of your choice via Cu-catalyzed azide-alkyne cycloaddition reactionAlkyne-containing Nucleosides
Nucleosides such as EdU (5-Ethynyl-2'-deoxyuridine) containing reactive triple bonds, allowing attachment of reporter groups by click chemistry techniquesAlkyne-containing Nucleotides
Nucleotides used to generate DNA containing reactive triple bonds, allowing attachment of reporter groups by click chemistry techniquesAlkyne-containing CEPs
Cyanoethyl-N,N-diisopropyl Phosphoramidites (CEPs) used to synthesize oligonucleotides by automated standard protocols. The resulting oligonucleotides contain triple bonds for attachment of azide-containing reporter groups.Alkyne-containing CPGs
CPGs (Controlled Pore Glasses) for the synthesis of oligonucleotides by automated standard protocols. The resulting oligonucleotides contain triple bonds for attachment of azide-containing reporter groups.Alkyne-containing Fluorescent Dyes
Fluorescent dyes containing reactive triple bonds for attachment to Azide-labeled molecules by click reactionsAlkyne-containing Spacers
Spacer building blocks containing reactive triple bondsAlkyne-containing Chemical Modification Reagents
Alkyne-containing reagents for introduction of functional groups, such as amines or NHS estersAuxiliary Reagents
Catalysts, ligands and solvents for click reactionsSelected references:
[1] Borsenberger et al. (2009) Diene-modified nucleotides for the Diels–Alder-mediated functional tagging of DNA. Nucleic Acids Research 37 (5):1477.
[2] Gramlich et al. (2008) Click–Click–Click: Single to Triple Modification of DNA. Angew. Chem. Int. Ed. 47:3442.
[3] Gramlich et al. (2008) Postsynthetic DNA Modification through the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction. Angew. Chem. Int. Ed. 47:8350.
[4] Seela et al. (2008) Modification of DNA with Octadiynyl Side Chains: Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne-Azide "Click" Reaction. Bioconjugate Chem. 19:211.
[5] Hammond et al. (2007) DNA Photography: An Ultrasensitive DNA-Detection Method Basedon Photographic Techniques. Angew. Chem. Int. Ed. 46:4184.
[6] Gierlich et al. (2007) Synthesis of Highly Modified DNA by a Combination of PCR with Alkyne-Bearing Triphosphates and Click Chemistry. Chem. Eur. J. 13:9486.
[7] Evans (2007) The Rise of Azide–Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and Surface Modification". Australian Journal of Chemistry 60 (6):384.
[8] Burley et al. (2006) Direct DNA Metallization. J. Am. Chem. Soc. 128:1398.
[9] Tornoe et al. (2002) Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides. Journal of Organic Chemistry 67 (9):3057.
[10] Kolb et al. (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40 (11):2004.
[11] Guida et al. (1996) Med. Res. Rev. p3.
For a comprehensive list of click chemistry related references, please see http://www.scripps.edu/chem/sharpless/click.html
[1] Borsenberger et al. (2009) Diene-modified nucleotides for the Diels–Alder-mediated functional tagging of DNA. Nucleic Acids Research 37 (5):1477.
[2] Gramlich et al. (2008) Click–Click–Click: Single to Triple Modification of DNA. Angew. Chem. Int. Ed. 47:3442.
[3] Gramlich et al. (2008) Postsynthetic DNA Modification through the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction. Angew. Chem. Int. Ed. 47:8350.
[4] Seela et al. (2008) Modification of DNA with Octadiynyl Side Chains: Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne-Azide "Click" Reaction. Bioconjugate Chem. 19:211.
[5] Hammond et al. (2007) DNA Photography: An Ultrasensitive DNA-Detection Method Basedon Photographic Techniques. Angew. Chem. Int. Ed. 46:4184.
[6] Gierlich et al. (2007) Synthesis of Highly Modified DNA by a Combination of PCR with Alkyne-Bearing Triphosphates and Click Chemistry. Chem. Eur. J. 13:9486.
[7] Evans (2007) The Rise of Azide–Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and Surface Modification". Australian Journal of Chemistry 60 (6):384.
[8] Burley et al. (2006) Direct DNA Metallization. J. Am. Chem. Soc. 128:1398.
[9] Tornoe et al. (2002) Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides. Journal of Organic Chemistry 67 (9):3057.
[10] Kolb et al. (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40 (11):2004.
[11] Guida et al. (1996) Med. Res. Rev. p3.
For a comprehensive list of click chemistry related references, please see http://www.scripps.edu/chem/sharpless/click.html