Products & Ordering

 

 User Login

You are not logged in

 

Order Information

 
Jena Bioscience at Google+ Jena Bioscience at Facebook
 
 
Catalog Unprotected Ribo-nucleosides - Alkyne-containing Ribo-NucleosidesUnprotected Ribo-nucleosides - Alkyne-containing Ribo-Nucleosides
 
 
Non-modified Ribo-nucleosides   |   Beta-L-ribo-nucleosides   |   5-Propynyl-ribo-nucleosides   |   7-Deaza-ribo-nucleosides   |   (O-allyl)-ribo-nucleosides   |   Alkyne-containing Ribo-Nucleosides   |   Etheno-ribo-nucleosides   |   Halogenated Ribo-nucleosides   |   Methylated Ribo-nucleosides   |   Thio-ribo-nucleosides   |   Other Modified Ribo-nucleosides
 
Nucleosides containing reactive groups (triple bonds) allow the attachment of reporter groups such as biotin or fluorescent dyes by means of click chemistry.

As EdU (5-Ethynyl-2'-deoxyuridine), a nucleoside analog of thymidine, is incorporated by proliferating cells, subsequent incubation of the cells with fluorescent azide facilitates the direct measurement of de novo DNA synthesis [1],[2],[3]. It can be used as a replacement for BrdU (5-Bromo-2'-deoxyuridine). Analog 5-Ethynyl-2'-deoxy-cytidine can be used to detect DNA synthesis with similar sensitivity as EdU [5].

Based on the same principle, 5-EU (5-Ethynyl-uridine) can be used for detection of RNA transcription and turnover in vivo. As it is incorporated into RNA transcripts, 5-EU-labeled cellular RNA can be detected quickly and with high sensitivity with fluorescent azides [4].

 

N6-Propargyl-Adenosine    
Product Cat. No. Amount Price (EUR) Buy / Note  
S pack CLK-N004-1 1 mg 68,50    Add this product to your notepad  
L pack CLK-N004-5 5 mg 274,00    Add this product to your notepad

 
5-Ethynyl-uridine (5-EU)    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-N002-10 10 mg 96,50    Add this product to your notepad  

 
2'-O-Propargyl Adenosine    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-RP-3401-10 10 mg 64,62    Add this product to your notepad  
100 mg pack CLK-RP-3401-100 100 mg 452,31    Add this product to your notepad

 
2'-O-Propargyl Cytidine    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-RP-3402-10 10 mg 64,62    Add this product to your notepad  
100 mg pack CLK-RP-3402-100 100 mg 452,31    Add this product to your notepad

 
2'-O-Propargyl Guanosine    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-RP-3403-10 10 mg 64,62    Add this product to your notepad  
100 mg pack CLK-RP-3403-100 100 mg 452,31    Add this product to your notepad

 
2'-O-Propargyl Uridine    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-RP-3404-10 10 mg 53,85    Add this product to your notepad  
100 mg pack CLK-RP-3404-100 100 mg 376,92    Add this product to your notepad

 
3'-O-Propargyl Adenosine    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-RP-3301-10 10 mg 51,69    Add this product to your notepad  
100 mg pack CLK-RP-3301-100 100 mg 361,85    Add this product to your notepad

 
3'-O-Propargyl Cytidine    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-RP-3302-10 10 mg 49,54    Add this product to your notepad  
100 mg pack CLK-RP-3302-100 100 mg 346,77    Add this product to your notepad

 
3'-O-Propargyl Guanosine    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-RP-3303-10 10 mg 56,00    Add this product to your notepad  
100 mg pack CLK-RP-3303-100 100 mg 392,00    Add this product to your notepad

 
3'-O-Propargyl Uridine    
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-RP-3304-10 10 mg 49,54    Add this product to your notepad  
100 mg pack CLK-RP-3304-100 100 mg 344,62    Add this product to your notepad

 
Selected references:
[1] Salic et al. (2008) A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc. Natl. Acad. Sci. USA 105 (7):2415.
[2] Doerr (2008) DNA synthesis lights up. Nature Methods 5 (4):286.
[3] Chehrehasa et al. (2009) EdU, a new thymidine analog for labeling proliferating cells in the nervous system. Journal of Neuroscience Methods 177:122.
[4] Jao et al. (2009) Exploring RNA transcription and turnover in vivo by using click chemistry. Proc. Nat. Acad. Sci. USA 105 (41):15779.
[5] Qu et al. (2011) 5-Ethynyl-2'-deoxycytidine as a new agent for DNA labeling: detection of proliferating cells. Anal Biochem 417(1):112.
 

Please contact info@jenabioscience.com with questions or inquiries.