. . PI3Kα, Jena Bioscience
Catalog PI3KαPI3Kα
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PI 3-Kinase alpha plays a specific role in apoptosis in human colon cancer cells. Injection of neutralizing antibodies specific to PI3Kα into adenocarcinoma cells induced apoptosis, a response that was reverted by treating cells with caspase inhibitor.
It was also shown that PI3Kα mediated phosphorylation of the p85α adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3-phosphorylated phosphoinositides. PI3Kα is a key regulator of the initiation of keratinocyte differentiation. A decrease in PI3Kα activity results in a loss of keratinocyte adhesion to the extracellular membrane and the initiation of early phase differentiation.

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Note: Bovine PI 3-Kinase alpha differs from the human enzyme in only 2 positions, K532R and S535C. Both lie in the PIK domain of the enzyme (aa 525-696) and are not expected to interfere with binding of p85 (aa 31-108) or Ras (aa 173-292) or with catalytic function (aa 699-1064).

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