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Alkyne-containing Reagents for Cu(I)-catalyzed Click Reactions
One of the most popular reactions within the click chemistry paradigm is the Cu(I)-catalyzed 1,3-dipolar Huisgen cycloaddition of alkynes and azides, using a Copper (Cu) catalyst at room temperature. This reaction proceeds with great efficiency and selectivity in aqueous media and yields a triazole moiety. |
Alkyne-containing Fluorescent Dyes
Fluorescent dyes containing reactive triple bonds for attachment to Azide-labeled molecules by click reactionsAlkyne-containing Biotinylation Reagents
Alkyne-containing reagents for the introduction of Biotin moietiesAlkyne-containing Chemical Modification Reagents
Alkyne-containing reagents for introduction of functional groupsAlkyne-containing Nucleotides
Nucleotides used to generate DNA containing reactive triple bonds, allowing attachment of reporter groups by click chemistry techniquesAlkyne-containing Nucleosides
Nucleosides such as EdU (5-Ethynyl-2'-deoxyuridine) containing reactive triple bonds, allowing attachment of reporter groups by click chemistry techniquesAlkyne-containing CEPs
Cyanoethyl-N,N-diisopropyl Phosphoramidites (CEPs) used to synthesize oligonucleotides by automated standard protocols. The resulting oligonucleotides contain triple bonds for attachment of azide-containing reporter groups.Alkyne-containing CPGs
CPGs (Controlled Pore Glasses) for the synthesis of oligonucleotides by automated standard protocols. The resulting oligonucleotides contain triple bonds for attachment of azide-containing reporter groups.Auxiliary Reagents
Catalysts, ligands and solvents for click reactionsAssay Kits
Easy to use kits containing all reagents required for the detection of cell proliferation via labeling of incorporated EdU by Cu-catalyzed azide-alkyne cycloaddition reactionClick Chemistry Kits
Easy to use kits containing all reagents required for labeling of alkyne-modified oligonucleotides or alkyne-modified PCR products with marker azides of your choice via Cu-catalyzed azide-alkyne cycloaddition reactionSelected references:
[1] Borsenberger et al. (2009) Diene-modified nucleotides for the Diels–Alder-mediated functional tagging of DNA. Nucleic Acids Research 37 (5):1477.
[2] Gramlich et al. (2008) Click–Click–Click: Single to Triple Modification of DNA. Angew. Chem. Int. Ed. 47:3442.
[3] Gramlich et al. (2008) Postsynthetic DNA Modification through the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction. Angew. Chem. Int. Ed. 47:8350.
[4] Seela et al. (2008) Modification of DNA with Octadiynyl Side Chains: Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne-Azide "Click" Reaction. Bioconjugate Chem. 19:211.
[5] Hammond et al. (2007) DNA Photography: An Ultrasensitive DNA-Detection Method Basedon Photographic Techniques. Angew. Chem. Int. Ed. 46:4184.
[6] Gierlich et al. (2007) Synthesis of Highly Modified DNA by a Combination of PCR with Alkyne-Bearing Triphosphates and Click Chemistry. Chem. Eur. J. 13:9486.
[7] Evans (2007) The Rise of Azide–Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and Surface Modification". Australian Journal of Chemistry 60 (6):384.
[8] Burley et al. (2006) Direct DNA Metallization. J. Am. Chem. Soc. 128:1398.
[9] Tornoe et al. (2002) Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides. Journal of Organic Chemistry 67 (9):3057.
[10] Kolb et al. (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40 (11):2004.
[11] Guida et al. (1996) Med. Res. Rev. p3.
For a comprehensive list of click chemistry related references, please see http://www.scripps.edu/chem/sharpless/click.html
[1] Borsenberger et al. (2009) Diene-modified nucleotides for the Diels–Alder-mediated functional tagging of DNA. Nucleic Acids Research 37 (5):1477.
[2] Gramlich et al. (2008) Click–Click–Click: Single to Triple Modification of DNA. Angew. Chem. Int. Ed. 47:3442.
[3] Gramlich et al. (2008) Postsynthetic DNA Modification through the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction. Angew. Chem. Int. Ed. 47:8350.
[4] Seela et al. (2008) Modification of DNA with Octadiynyl Side Chains: Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne-Azide "Click" Reaction. Bioconjugate Chem. 19:211.
[5] Hammond et al. (2007) DNA Photography: An Ultrasensitive DNA-Detection Method Basedon Photographic Techniques. Angew. Chem. Int. Ed. 46:4184.
[6] Gierlich et al. (2007) Synthesis of Highly Modified DNA by a Combination of PCR with Alkyne-Bearing Triphosphates and Click Chemistry. Chem. Eur. J. 13:9486.
[7] Evans (2007) The Rise of Azide–Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and Surface Modification". Australian Journal of Chemistry 60 (6):384.
[8] Burley et al. (2006) Direct DNA Metallization. J. Am. Chem. Soc. 128:1398.
[9] Tornoe et al. (2002) Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides. Journal of Organic Chemistry 67 (9):3057.
[10] Kolb et al. (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40 (11):2004.
[11] Guida et al. (1996) Med. Res. Rev. p3.
For a comprehensive list of click chemistry related references, please see http://www.scripps.edu/chem/sharpless/click.html