Catalog PI 3-Kinase Family - PI3KαPI 3-Kinase Family - PI3Kα
 
 
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PI3Kα   |   PI3Kβ   |   PI3Kγ   |   PI3Kδ   |   Adaptor Proteins   |   Substrates   |   Inhibitors   |   PI3K Assay
 
PI 3-Kinase alpha plays a specific role in apoptosis in human colon cancer cells. Injection of neutralizing antibodies specific to PI3Kα into adenocarcinoma cells induced apoptosis, a response that was reverted by treating cells with caspase inhibitor.
It was also shown that PI3Kα mediated phosphorylation of the p85α adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3-phosphorylated phosphoinositides. PI3Kα is a key regulator of the initiation of keratinocyte differentiation. A decrease in PI3Kα activity results in a loss of keratinocyte adhesion to the extracellular membrane and the initiation of early phase differentiation.
 

Product Accession No. Cat. No. Amount Price (EUR) Buy / Note Downloads
PI 3-Kinase α His
Phosphoinositide 3-Kinase α His, p110αHis/p85α
human, recombinant, Sf9 insect cells
HSU79143 / NM_181523 PR-335 10 g 159,00    Add this product to your notepad  
PI 3-Kinase α (bovine)
Phosphoinositide 3-Kinase α, p110α/p85α
bovine, recombinant, Sf9 insect cells
NM_174574 / NM_174575 PR-341 10 g 130,00    Add this product to your notepad  
p85 α
Phosphoinositide 3-Kinase regulatory subunit
bovine, recombinant, Leishmania tarentolae
NM_174575 PR-342 20 g 190,00    Add this product to your notepad  
p85 β
Phosphoinositide 3-Kinase regulatory subunit
bovine, recombinant, Sf9 insect cells
NP_777001.1 PR-942 10 g 190,00    Add this product to your notepad  

Note: Bovine PI 3-Kinase alpha differs from the human enzyme in only 2 positions, K532R and S535C. Both lie in the PIK domain of the enzyme (aa 525-696) and are not expected to interfere with binding of p85 (aa 31-108) or Ras (aa 173-292) or with catalytic function (aa 699-1064).
 

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