Catalog Protein Prenylation - Lipid DonorsProtein Prenylation - Lipid Donors
 
 
Protein Prenyl Transferases   |   Lipid Donors   |   FTase Substrates and Related Proteins   |   GGTase-I Substrates and Related Proteins   |   RabGGTase Substrates and Related Proteins   |   Inhibitors
 
Innovative lipid donors have been developed for sensitive prenylation assays. NBD-FPP and NBD-GPP are a well-established fluorescent analogs of the natural lipid donors.
B-GPP is the first universal lipid donor for all prenylatable proteins, providing versatile prenylation assays with femtomolar detection sensitivity.
 

Product Cat. No. Amount Price (EUR) Buy / Note Downloads
B-GPP
Biotin-labeled geranyl pyrophosphate, triethylammonium salt
LI-015 20 l 180,00    Add this product to your notepad  
NBD-FPP
{3,7,11-trimethyl-12-(7-nitro-benzo[1,2,5]oxadiazo-4-ylamino)
-dodeca-2,6,10-trien-1} pyrophosphate

Fluorescent lipid donor for protein geranylgeranyltransferases (RabGGTase, GGTase-I)
LI-013 20 l 180,00    Add this product to your notepad  
NBD-GPP
3,7-dimethyl-8-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)
-octa-2,6-diene-1- pyrophosphate

Fluorescent lipid donor for protein farnesyltransferase (FTase)
LI-014 20 l 180,00    Add this product to your notepad  
FPP
Farnesyl pyrophosphate, ammonium salt
Natural lipid donor for protein farnesyltransferase (FTase)
LI-016 200 g 128,00    Add this product to your notepad  
GGPP
Geranylgeranyl pyrophosphate, ammonium salt
Natural lipid donor for protein geranylgeranyltransferases (RabGGTase, GGTase-I)
LI-017 200 g 128,00    Add this product to your notepad  

Selected References

  • Nguyen et al. (2009) Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nature Chemical Biology. 5 (4):227
  • Wu et al. (2007) Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase. Nat. Protoc. 2 (11):2704
  • Dursina et al. (2006) Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J. Am. Chem. Soc. 128 (9):2822
 
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