Catalog PI 3-Kinase Family - PI3KγPI 3-Kinase Family - PI3Kγ
 
 
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PI3Kα   |   PI3Kβ   |   PI3Kγ   |   PI3Kδ   |   Adaptor Proteins   |   Substrates   |   Inhibitors   |   PI3K Assay
 
PI 3-Kinase gamma is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kγ-/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8α-DCs.
In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3Kγ.
 

Product Accession No. Cat. No. Amount Price (EUR) Buy / Note Downloads
PI 3-Kinase γ His
Phosphoinositide 3-Kinase γ His, p110γHis
human, recombinant, Sf9 cells
NM_002649 / NP_002640 PR-343 10 g 130,00    Add this product to your notepad  
PI 3-Kinase γ D946A GST
Phosphoinositide 3-Kinase γ GST, p110γGST, inactive mutant
human, recombinant, Sf9 cells
NM_002649 / NP_002640 PR-346 10 g 130,00    Add this product to your notepad  

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