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Protein Prenylation - Protein Prenyl TransferasesProtein Prenyl Transferases
| Lipid Donors
| FTase Substrates and Related Proteins
| GGTase-I Substrates and Related Proteins
| RabGGTase Substrates and Related Proteins
| Inhibitors
FTase and GGTase-I are designated CaaX prenyltransferases, since they recognize their protein substrates by the so-called CaaX-box. Both enzymes share a common α subunit (48 kDa) and a homologous β subunit (46 kDa in FTase, 42 kDa in GGTase-I). GGTase-II or RabGGTase differs from FTase and GGTase-I, both structurally and functionally. The enzyme attaches geranylgeranyl groups to two C-terminal cysteines of Rab proteins that terminate in CC or CXC motifs.
Engineered mutants of FTase (Cat.# PR-952 and PR-953) and GGTase-I (Cat.# PR-954) in combination with our innovative and universal lipid donor B-GPP (Cat.# LI-015) allow the detection of femtomolar amounts of prenylatable proteins in eukaryotic cells and tissues and thereby offer a new generation of prenylation studies.
Engineered mutants of FTase (Cat.# PR-952 and PR-953) and GGTase-I (Cat.# PR-954) in combination with our innovative and universal lipid donor B-GPP (Cat.# LI-015) allow the detection of femtomolar amounts of prenylatable proteins in eukaryotic cells and tissues and thereby offer a new generation of prenylation studies.
| Product | Accession No. | Cat. No. | Amount | Price (EUR) | Buy / Note | Downloads |
|---|---|---|---|---|---|---|
| FTase Protein farnesyltransferase, α- and β-subunit rat, recombinant, E. coli |
Q04631 / Q02293 | PR-102 | 50 µg | 180,00 | 
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| FTaseGST Protein farnesyltransferase, α- and β-subunit rat, recombinant, E. coli |
Q04631 / Q02293 | PR-361 | 50 µg | 180,00 |
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| FTaseW102T_Y154TGST Protein farnesyltransferase mutant, α- and β-subunit rat, recombinant, E. coli |
PR-952 | 20 µg | 245,00 |
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| FTaseW102T_Y154T_Y205TGST Protein farnesyltransferase mutant, α- and β-subunit rat, recombinant, E. coli |
PR-953 | 20 µg | 245,00 |
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| GGTase-I Protein geranylgeranyltransferase type I rat, recombinant, E. coli |
NM_031082 | PR-101 | 50 µg | 180,00 |
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| GGTase-IGST Protein geranylgeranyltransferase type I rat, recombinant, E. coli |
NM_031082 | PR-360 | 50 µg | 180,00 |
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| GGTase-IF53Y_Y126TGST Protein geranylgeranyltransferase type I mutant, α- and β-subunit rat, recombinant, E. coli |
PR-954 | 20 µg | 245,00 |
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| GGTase-II (RabGGTase) Protein geranylgeranyltransferase type II, α- and β-subunit rat, recombinant, E. coli |
Q08602 / Q08603 | PR-103 | 50 µg | 180,00 |
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| REP-1His Rab Escort Protein rat, recombinant, Sf9 insect cells |
1LTXP | PR-105 | 50 µg | 180,00 |
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| REP-2His Rab Escort Protein human, recombinant, Saccharomyces cerevisiae |
NM_001821 | PR-104 | 50 µg | 180,00 |
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Selected References
- Hougland et al. (2009) Getting a handle on protein prenylation. Nat. Chem. Biol. 5 (4):197
- Nguyen et al. (2009) Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat. Chem. Biol. 5 (4):227
- Lane et al. (2006) Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. J. Lipid Res. 47:681
- Casey et al. (1996) Protein Prenyltransferases. J. Biol. Chem. 271 (10):5289
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