. . PI3Kδ, Jena Bioscience
Catalog PI3KδPI3Kδ
PI 3-Kinase delta is expressed in endothelial and in white blood cells. Recently it was shown that the inactivation of PI3Kδ in bone marrow mast cells (BBMCs) leads to defective stem cell factor-mediated proliferation, adhesion and migration of these cells, and to impaired allergen-IgE-induced degranulation and cytokine release.
In neutrophils a role for PI3Kδ in TNFα-induced signalling was demonstrated by a reduction in Akt-phosphorylation and PDK1 activity upon treatment with the δ-specific inhibitor IC87114.

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