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PI 3-Kinase Family - PI3Kγ |
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PI 3-Kinase gamma is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kγ-/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8α-DCs.
In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3Kγ.
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PI 3-Kinase gamma His
Phosphoinositide 3-Kinase γ His, p110γHis
human, recombinant, Sf9 cells |
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NM_002649 / NP_002640 |
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PR-343 |
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10 µg |
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130,00 |
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PI 3-Kinase gamma D946A GST
Phosphoinositide 3-Kinase γ GST, p110γGST, inactive mutant
human, recombinant, Sf9 cells |
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NM_002649 / NP_002640 |
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PR-346 |
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10 µg |
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130,00 |
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