Catalog Bifunctional reagents - Trans-Cyclooctene-(functional group)Bifunctional reagents - Trans-Cyclooctene-(functional group)
 
 
Azide-(functional group)   |   Alkyne-(functional group)   |   DBCO-(functional group)   |   Tetrazine-(functional group)   |   Trans-Cyclooctene-(functional group)
 
Trans-Cyclooctene-containing bifunctional reagents can be used for the introduction of

  • a functional group (e.g. Amine or NHS Ester) to Tetrazine-labeled molecules via Cu-free Click Chemistry
  • an Cyclooctene group to various targets e.g. via NHS Ester- or Maleimide-based chemistry
Click Chemistry background information
 


Table 1: Available Trans-Cyclooctene-containing Bifunctional Reagents

Reactive GroupTrans-Cyclooctene
NHS esterTCO-NHS ester
TCO-PEG4-NHS ester
UV-Tracer™ TCO-NHS ester
MaleimideTCO-PEG3-Maleimide
Amine (-NH2)TCO-Amine
DBCOTCO-PEG12-DBCO
 

TCO-NHS ester
trans-Cyclooctene-NHS ester
   
Product Cat. No. Amount Price (EUR) Buy / Note  
25 mg pack CLK-1016-25 25 mg 270,45    Add this product to your notepad  
100 mg pack CLK-1016-100 100 mg 717,50    Add this product to your notepad
1 g pack CLK-1016-1G 1 g 4.139,42    Add this product to your notepad

 
TCO-PEG4-NHS ester
trans-Cyclooctene-PEG4-NHS ester
   
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-A137-10 10 mg 132,46    Add this product to your notepad  
100 mg pack CLK-A137-100 100 mg 877,55    Add this product to your notepad

 
UV-Tracer™ TCO-NHS ester
UV-Tracer™ trans-Cyclooctene-NHS ester
   
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-1031-10 10 mg 164,47    Add this product to your notepad  
100 mg pack CLK-1031-100 100 mg 987,95    Add this product to your notepad

 
TCO-PEG3-Maleimide
trans-Cyclooctene-PEG3-Maleimide
   
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-1002-10 10 mg 132,46    Add this product to your notepad  
100 mg pack CLK-1002-100 100 mg 877,55    Add this product to your notepad

 
TCO-Amine
trans-Cyclooctene-Amine
   
Product Cat. No. Amount Price (EUR) Buy / Note  
25 mg pack CLK-1021-25 25 mg 270,45    Add this product to your notepad  
100 mg pack CLK-1021-100 100 mg 717,50    Add this product to your notepad
1 g pack CLK-1021-1G 1 g 4.139,42    Add this product to your notepad

 
TCO-PEG12-DBCO
trans-Cyclooctene-PEG12-Dibenzylcyclooctyne
   
Product Cat. No. Amount Price (EUR) Buy / Note  
10 mg pack CLK-1005-10 10 mg 132,46    Add this product to your notepad  
100 mg pack CLK-1005-100 100 mg 877,55    Add this product to your notepad

 

Selected References:

[1] Selvaraj et al. (2013) trans-Cyclooctene - a stable voracious dienophile for bioorthogonal labeling. Current Opinion in Chemical Biology 17:753.
 


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