Catalog Phasing Kits - JBS Tungsten Cluster Derivatization Kits Phasing Kits - JBS Tungsten Cluster Derivatization Kits
 
 

Application

Heavy atom derivatization of biological macromolecules for isomorphous and/or anomalous phasing methods.
Experimental Tungsten (W) Phasing either by SAD/MAD or MIR experiments has become increasingly popular due to the high electron-density and good solubility in aqueous solutions of Polyoxotungstate Clusters.

 

The Tungstate Cluster Kits consist of 6 ready-to-use aliquots of Phosphotungstate, Metatungstate or Paratungstate salts, respectively. All Tungsten clusters contain 12 Tungsten metal centers bridged by Oxygen atoms, but differ in their resulting negative charge (3-, 6- and 10-, respectively).
 


Video Metatungstate Cluster still
Metatungstate-cluster bound to a positively charged surface patch of the death receptor 6 (DR6) (Dahms et al., 2013).

Move the mouse pointer over the image to start the animation.
 

Product Cat. No. Amount Price (EUR) Buy / Note Downloads
JBS Phosphotungstate Cluster Kit PK-105 21 mg
(6 x 3,5 mg)
161,00    Add this product to your notepad  
JBS Metatungstate Cluster Kit PK-106 21 mg
(6 x 3,5 mg)
161,00    Add this product to your notepad  
JBS Paratungstate Cluster Kit PK-107 21 mg
(6 x 3,5 mg)
161,00    Add this product to your notepad  
JBS Tungstate Cluster Kit
contains 3 different clusters
PK-108 10,5 mg
(3 x 3,5 mg)
109,00    Add this product to your notepad  

References

  • Rudenko et al. (2003) 'MAD'ly phasing the extracellular domain of the LDL receptor: a medium-sized protein, large tungsten clusters and multiple non-isomorphous crystals. Acta Cryst. D59:1978.
 

Selected Literature Citations of JBS Tungsten Cluster Derivatization Kits

  • Dahms et al. (2013) Localization and orientation of heavy-atom cluster compounds in protein crystals using molecular replacement. Acta Cryst. D69:284.
 
Please contact xtals@jenabioscience.com with questions or inquiries.