The PurePEGs Screen features conditions with a mixture of purified PEGs, ranging from 300 MW to 8,000 MW. At a total PEG concentration of 22.5 % [1], combined with various salts and buffers, the conditions are designed to give the most crystallization hits spanning a wide pH range (1.1 - 9.8).

Features:

• Ultra pure PEGs – USP grade
• Optimized for diffusive mixing; capillary crystallization
• Polydispersed PEGs; 5 PEGs in each condition
• pH measured and recorded for final solution
• Better control of manufacturing impurities in the PEGs

   Background

[1] Newman et al. (2005) Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy. Acta Cryst. D61:1426.
[2] Page et al. (2003) Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome. Acta Cryst. D59:1028.
[3] Wooh et al. (2003) Comparison of three commercial sparse-matrix crystallization screens. Acta Cryst. D59:769.
[4] Bukrinsky et al. (2001) pH, conductivity and long-term stability in the Crystal Screen solutions. J. Appl. Cryst.34:533.

Please contact xtals@jenabioscience.com with questions or inquiries.