JBS Magic Triangle is a phasing kit developed in co-operation with Tobias Beck in the research group of Prof. George M. Sheldrick, Georg-August University Göttingen.

I3C - the magic triangle - is depicted to the right. The three iodine atoms form an equilateral triangle with a side length of 6.0 Å and can be readily identified in the anomalous electron density map [1].

The researchers in the Sheldrick group have successfully demonstrated that I3C can be utilized for heavy-atom derivatization of biological macromolecules. Experimental phases for several proteins have been derived using single-wavelength anomalous dispersion (SAD) or single isomorphous replacement plus anomalous scattering (SIRAS) methods [1,2].

• Beck et al. (2008) A magic triangle for experimental phasing of macromolecules. Acta Cryst. D64:1179.
• Sippel et al. (2008) Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37. Acta Cryst. D64:1172.

Please contact xtals@jenabioscience.com with questions or inquiries.
For technical questions you may also contact tobiasbeck@gmail.com