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Jena Bioscience distributes Microlytic's innovative microfluidic devices
 
Microlytic uses microfluidic technology to minimize major problems in structural biology. Microlytic has combined its strengths in microfabrication, surface chemistry and fluid physics to develop innovative devices that offer researchers easy-of-use, improved success rates and superior output. The Crystal Former™ is the first product developed by Microlytic addressing the major bottleneck in structural biology of obtaining high quality crystals.

 
Xtals Microlytic

The Crystal Former™ is a microfluidic device for protein crystallization that exploits the favorable physical conditions occurring at the microscale. This environment, when combined with the Crystal Former's special materials, unique surface treatment, and proprietary mixing kinetics substantially improve crystallization success.
Each capillary's continuous gradient enables screening a vast number of conditions, comparable to doing hundreds of individual experiments using other technologies. This means more rapid identification of initial crystallization conditions and the identification of multiple crystal forms.
Key advantages:
  • High-output redefined: Maximum crystallization probability on one plate
  • Simple to use, no external equipment is required, automatable, ready to add to any workflow
  • Low protein consumption
  • Direct Access to crystals for harvesting
 
What is high output crystallization?
Exemplified by the Microlytic SBS High Throughput Crystal Former, high output crystallization experiments are trials in which the number of crystallization events is generally large relative to conventional experiments. Such systems explore a much greater area of crystallization space with fewer discrete crystallization conditions and low protein consumption. As offered by the Crystal Former, ideal high output crystallization platforms also feature:
  • Increased probability of crystallization success
  • Systematic screening for which the output is easy to interpret and highly informative, even in the absence of crystals
  • Non-redundant exploration of crystallization space
  • Easy integration into all structural biology platforms, including cross-platform robotic compatibility
 
Xtals Microlytic

How does the Crystal Former return high output crystallization data?
The Crystal Former comprises 96 U-shaped channels in which protein crystallization is driven by liquid-liquid diffusion. The protein sample is first loaded into the channel, which fills only by capillary action. The crystallization reagent is then loaded into the opposing inlet. Equilibration of these solutions occurs through diffusion within the microchannels, during which a complex gradient of all the mixture components is transiently established. Through this gradient, the behavior of the protein target is explored with infinite sampling. This continuous exploration of crystallization space for a discrete condition is virtually impossible to capture in other crystallization formats and returns a tremendous amount of information on a per-trial basis, allowing the user to observe all possible experimental outcomes in a single microchannel.
 

High Throughput Crystallization Kit

This starter kit contains everything needed for crystallization screening with the Crystal Former, compatible with both automated and manual set-up.
 

Crystal Formers™

Microfluidic devices for protein crystallization that exploit the favorable physical conditions occurring at the microscale. Available in various formats: from the original one to the SBS High-throughput Crystal Former.
 

Crystallization Screens

Discover Microlytic's SuperCOMBI and PurePEGs Screen arranged for compatibility with the SBS High Throughput Crystal Former.
 

Accessories

Tools to complement your Crystal Former System.