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PI 3-Kinase Family - PI3Kδ |
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PI 3-Kinase delta is expressed in endothelial and in white blood cells. Recently it was shown that the inactivation of PI3Kδ in bone marrow mast cells (BBMCs) leads to defective stem cell factor-mediated proliferation, adhesion and migration of these cells, and to impaired allergen-IgE-induced degranulation and cytokine release.
In neutrophils a role for PI3Kδ in TNFα-induced signalling was demonstrated by a reduction in Akt-phosphorylation and PDK1 activity upon treatment with the δ-specific inhibitor IC87114.
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Accession No. |
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Downloads |
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PI 3-Kinase delta GST
Phosphoinositide 3-Kinase δ GST, p110δGST/p85α
human, recombinant, Sf9 cells |
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O00329 |
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PR-345 |
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10 µg |
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180,00 |
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p85 alpha
Phosphoinositide 3-Kinase regulatory subunit
bovine, recombinant, Leishmania tarentolae |
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NM_174575 |
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PR-342 |
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20 µg |
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190,00 |
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p85 beta
Phosphoinositide 3-Kinase regulatory subunit
bovine, recombinant, Sf9 cells |
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NP_777001.1 |
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PR-942 |
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10 µg |
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190,00 |
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